When kissing (disease) counts

Interstitial nephritis: another kissing disease?

Accurate When It Counts – 1 Accurate When It Counts: Perceiving Power and Status in Social Groups

Several years ago, one of us came across an advice book titled 30 Things Everyone Should Know How To Do Before Turning 30 (Adcock, 2003). Said milestone having already passed, your correspondent was interested in knowing what crucial age-appropriate expertise he did or did not possess, intending to brush up if needed. Amid instructions on how to change a car tire (check), open a Champagne bottl...

X Chromosome Inactivation: When Dosage Counts

How do mammals count their X chromosomes and keep only one X active per cell? In this issue, Jonkers et al. (2009) show that Rnf12/RLIM, encoded by the X-linked gene Rnf12, induces X chromosome inactivation only when present above a certain threshold, a condition fulfilled when at least two Xs are active.

When Time Counts Rely on Teleflex

The current Tactical Combat Casualty Care (TCCC) Guidelines recommend parenteral promethazine as the single agent for the treatment of opioid-induced nausea and/or vomiting and give a secondary indication of “synergistic analgesic effect.” Promethazine, however, has a well-documented history of undesired side effects relating to impairment and dysregulation of the central and autonomic nervous ...

Monocyte phenotypes: When local education counts

432 INSIGHTS | The Journal of Experimental Medicine Monocytes are a heterogeneous population of phagocytic cells that are generated in the bone marrow and released into the bloodstream. There are two main monocyte subsets in mice: “inflammatory” monocytes that are Ly6C CCR2 CX 3 CR1 and “alternative” or “patrolling” monocytes that are Ly6C CCR2 CX 3 CR1. The process of monocyte recruitment and ...